Article Respiratory System
Baseline Sex Differences in Pulmonary Arterial Hypertension Randomized Clinical Trials
Corey E. Ventetuolo, Jude Moutchia, Grayson L. Baird, Dina H. Appleby, Robyn L. McClelland, Jasleen Minhas, Jeff Min, John H. Holmes, Ryan J. Urbanowicz, Nadine Al-Naamani, Steven M. Kawut
Summary: This study found that sex differences have an impact on baseline 6-minute walk distance, hemodynamics, and functional class in pulmonary arterial hypertension (PAH). Females had shorter 6MWD, higher cardiac index, and lower right atrial pressure and mean pulmonary artery pressure. Age and body mass index modulated the relationship between sex and these outcomes. The study suggests that sex, age, and body size should be taken into consideration in the evaluation and interpretation of surrogate outcomes in PAH.
ANNALS OF THE AMERICAN THORACIC SOCIETY (2023)
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Review Critical Care Medicine
The statistical fragility of the distal fibula fracture literature: A systematic review of randomized controlled trials
Hassan Mian, Michael Megafu, Emmanuel Megafu, Sulabh Singhal, Nicholas. G. Richardson, Paul Tornetta III, Robert. L. Parisien
Summary: The purpose of this study was to evaluate the statistical fragility in the distal fibular fracture literature using the fragility index (FI) and fragility quotient (FQ). Six randomized controlled trials were analyzed and it was found that the overall FI and FQ were 5 and 0.089, respectively. The study suggests that relying solely on a P value threshold for statistical analysis in the literature may be misleading, and standardized reporting of P value, FI, and FQ can help draw reliable conclusions based on outcome fragility.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2023)
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Article Cardiac & Cardiovascular Systems
Pulmonary Artery Denervation for Pulmonary Arterial Hypertension A Sham-Controlled Randomized PADN-CFDA Trial
Hang Zhang, Yongyue Wei, Caojin Zhang, Zhenwen Yang, Jing Kan, Heping Gu, Fenling Fan, Hong Gu, Qiguang Wang, Dujiang Xie, Gangcheng Zhang, Xiaomei Guo, Yuehui Yin, Bowen Jin, Hongmei Zhou, Ziyang Yang, Zhouming Wang, Yu Xin, Chen Zhang, Lili Meng, Xiaoyu Wang, Jingping Sun, Chunxia Zhao, Juan Zhang, Xiaoyan Yan, Feng Chen, Cheng Yao, Gregg W. Stone, Shao-Liang Chen
Summary: This study aimed to evaluate the treatment effects of pulmonary artery denervation (PADN) in patients with pulmonary arterial hypertension (PAH). The results showed that PADN improved exercise capacity, hemodynamic status, and clinical outcomes in PAH patients.
JACC-CARDIOVASCULAR INTERVENTIONS (2022)
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Review Orthopedics
The Fragility of Statistical Significance in Patellofemoral Instability Research: A Systematic Review
Michael Constant, David P. Trofa, Bryan M. Saltzman, Christopher S. Ahmad, Xinning Li, Robert L. Parisien
Summary: The fragility analysis of patellofemoral instability (PFI) literature revealed a lack of robustness in the reported results, with only a few outcome events required to reverse statistical significance. It is recommended to triple report the P value, FI, and FQ in future comparative trials in the PFI literature to aid in the interpretation of statistical integrity.
AMERICAN JOURNAL OF SPORTS MEDICINE (2022)
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Article Medicine, General & Internal
Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension
Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Vallerie V. McLaughlin, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Ekkehard Gruenig, Grzegorz Kopec, Gisela Meyer, Karen M. Olsson, Stephan Rosenkranz, Yayun Xu, Barry Miller, Marcie Fowler, John Butler, Joerg Koglin, Janethe de Oliveira Pena, Marc Humbert
Summary: This study confirms that in patients with stable background therapy, sotatercept can significantly improve the exercise capacity of patients with pulmonary arterial hypertension compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE (2023)
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Review Orthopedics
The fragility of statistical findings in distal biceps tendon repairs: a systematic review of randomized controlled trials
Michael N. Megafu, Hassan S. Mian, Mahad M. Hassan, Bradford O. Parsons, Xinning Li, Robert L. Parisien
Summary: The purpose of this study was to assess the robustness of RCTs evaluating distal biceps tendon repairs through fragility analysis. The results suggest that the dichotomous outcomes were statistically fragile, and statistically significant outcomes had higher fragility compared to other orthopedic specialties.
JOURNAL OF SHOULDER AND ELBOW SURGERY (2023)
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Article Cardiac & Cardiovascular Systems
Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial
Ekkehard Gruenig, Alison MacKenzie, Andrew J. Peaco*ck, Christina A. Eichstaedt, Nicola Benjamin, Robert Nechwatal, Silvia Ulrich, Stephanie Saxer, Maurizio Bussotti, Marinella Sommaruga, Stefano Ghio, Lina Gumbiene, Egle Paleviciute, Elena Jureviciene, Antonio Cittadini, Anna A. Stanziola, Alberto M. Marra, Gabor Kovacs, Horst Olschewski, Joan-Albert Barbera, Isabel Blanco, Martijn A. Spruit, Frits M. E. Franssen, Anton Vonk Noordegraaf, Abilio Reis, Mario Santos, Sofia Goncalves Viamonte, Heleen Demeyer, Marion Delcroix, Eduardo Bossone, Martin Johnson
Summary: This study is the first multicentre and largest randomized, controlled study on the feasibility, safety, and efficacy of exercise training as add-on to medical therapy in PAH and CTEPH patients, showing that exercise training can improve patients' exercise capacity, quality of life, and WHO functional class.
EUROPEAN HEART JOURNAL (2021)
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Article Cardiac & Cardiovascular Systems
Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial
Ekkehard Gruenig, Alison MacKenzie, Andrew J. Peaco*ck, Christina A. Eichstaedt, Nicola Benjamin, Robert Nechwatal, Silvia Ulrich, Stephanie Saxer, Maurizio Bussotti, Marinella Sommaruga, Stefano Ghio, Lina Gumbiene, Egle Paleviciute, Elena Jureviciene, Antonio Cittadini, Anna A. Stanziola, Alberto M. Marra, Gabor Kovacs, Horst Olschewski, Joan-Albert Barbera, Isabel Blanco, Martijn A. Spruit, Frits M. E. Franssen, Anton Vonk Noordegraaf, Abilio Reis, Mario Santos, Sofia Goncalves Viamonte, Heleen Demeyer, Marion Delcroix, Eduardo Bossone, Martin Johnson
Summary: This study demonstrated that exercise training for patients with PAH and CTEPH can significantly improve quality of life, WHO functional class, and peak oxygen consumption, and is feasible, safe, and well-tolerated as an add-on to medical therapy.
EUROPEAN HEART JOURNAL (2021)
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Article Respiratory System
Secular and Regional Trends among Pulmonary Arterial Hypertension Clinical Trial Participants
Jeff Min, Dina H. Appleby, Robyn L. McClelland, Jasleen Minhas, John H. Holmes, Ryan J. Urbanowicz, Steven C. Pugliese, Jeremy A. Mazurek, K. Akaya Smith, Jason S. Fritz, Harold Palevsky, Jude Moutchia Suh, Nadine Al-Naamani, Steven M. Kawut
Summary: The population of patients in pulmonary arterial hypertension (PAH) trials has changed over time, with older and more obese participants enrolling in recent years. These trends reflect the changing epidemiology of PAH cohorts and vary by geographic region. The majority of participants in these trials are still female, posing challenges for generalizability to male patients. Recruitment in Asia and Latin America has contributed to an increase in non-White participants in recent years.
ANNALS OF THE AMERICAN THORACIC SOCIETY (2022)
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Review Orthopedics
Statistical Fragility of Randomized Controlled Trials Evaluating Rehabilitation After Arthroscopic Rotator Cuff Repair
Sean B. B. Sequeira, Melissa A. A. Wright, Anand M. M. Murthi
Summary: This study conducted a systematic review of randomized controlled trials (RCTs) on rehabilitation protocols after rotator cuff repair (RCR). The results showed that the study findings have a certain fragility, and caution should be exercised when applying them in clinical practice.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE (2023)
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Review Medicine, General & Internal
Clinical features of pulmonary arterial hypertension associated with systemic sclerosis
Tijana Tuhy, Paul M. Hassoun
Summary: Systemic sclerosis is an autoimmune disorder that affects the connective tissue and causes skin thickening and complications in the internal organs. Pulmonary involvement, including pulmonary arterial hypertension and interstitial lung disease, is the main cause of morbidity and mortality in scleroderma patients. Current treatment options are not specific to pulmonary involvement in scleroderma, and patients with pulmonary arterial hypertension in this population tend to have worse outcomes and lower response to therapy compared to other forms of Group I pulmonary hypertension.
FRONTIERS IN MEDICINE (2023)
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Article Cardiac & Cardiovascular Systems
Clinical Implications of Body Composition and Exercise Capacity Following Pulmonary Endarterectomy
Indranil Balki, Marc de Perrot, Fatemeh Bavaghar-Zaeimi, Sahar Nourouzpour, John T. Granton, John Thenganatt, Micheal McInnis, Karen McRae, Laura Donahoe, Dmitry Rozenberg
Summary: This study aimed to investigate the association of body composition and exercise capacity with disease severity, hospital length of stay, discharge disposition, and postoperative functional recovery in patients undergoing pulmonary endarterectomy (PEA). The results showed that exercise capacity was a more prognostic marker of PEA outcomes compared with body composition.
ANNALS OF THORACIC SURGERY (2022)
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Article Critical Care Medicine
ST2 Is a Biomarker of Pediatric Pulmonary Arterial Hypertension Severity and Clinical Worsening
Megan Griffiths, Jun Yang, Catherine E. Simpson, Dhananjay Vaidya, Melanie Nies, Stephanie Brandal, Rachel Damico, D. Dunbar Ivy, Eric D. Austin, Michael W. Pauciulo, Katie A. Lutz, Erika B. Rosenzweig, Russel Hirsch, Delphine Yung, William C. Nichols, Allen D. Everett
Summary: In two pediatric PAH cohorts, elevated ST2 was associated with unfavorable pulmonary hemodynamics and functional measures, clinical worsening, and significantly improved prediction of clinical worsening. Pulmonary artery endothelial cellular expression of ST2 suggests that ST2 is a more pulmonary vascular-specific marker for pulmonary hypertension.
CHEST (2021)
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Article Geriatrics & Gerontology
Effectiveness of the fall prevention intervention in older adults with arterial hypertension: randomized clinical trial
Francisca Valuzia Guedes Guerra, Rafaella Pessoa Moreira, Glauciano de Oliveira Ferreira, Janiel Ferreira Felicio, Tahissa Frota Cavalcante, Thelma Leite de Araujo, Marcio Flavio Moura de Araujo
Summary: The study aimed to evaluate the effectiveness of the nursing intervention Fall Prevention in reducing falls in older adults with arterial hypertension. Results showed a significant difference in the frequency of self-reported falls between the intervention and control groups, with fewer falls occurring in the intervention group. The nursing intervention was effective in reducing the occurrence of falls in older adults with arterial hypertension.
GERIATRIC NURSING (2021)
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Article Critical Care Medicine
Effect of Normobaric Hypoxia on Exercise Performance in Pulmonary Hypertension Randomized Trial
Simon R. Schneider, Laura C. Mayer, Mona Lichtblau, Charlotte Berlier, Esther I. Schwarz, Stephanie Saxer, Michael Furian, Konrad E. Bloch, Silvia Ulrich
Summary: In patients with pulmonary hypertension, exposure to hypoxia led to a shorter constant work-rate exercise test time compared to normoxia, accompanied by hypoxemia, lactacidemia, and hypocapnia. However, pulmonary hemodynamics and dyspnea remained unchanged, indicating that the exercise limitation induced by hypoxia may be due to reduced oxygen delivery causing peripheral tissue hypoxia, increased lactic acid production, and hyperventilation.
CHEST (2021)
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Editorial Material Medicine, General & Internal
Peliosis hepatis and systemic lupus erythematosus: A rare condition identified by magnetic resonance imaging
Rafael Alves Cordeiro, Leonardo Santos Hoff, Marcos Vinicius Fernandes Garcia, Hilton Muniz Leao Filho, Eduardo Ferreira Borba
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2018)
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Article Cardiac & Cardiovascular Systems
Outcomes and prognostic factors of decompensated pulmonary hypertension in the intensive care unit
Marcos Vinicius Fernandes Garcia, Rogerio Souza, Eduardo Leite Vieira Costa, Caio Julio Cesar Santos Fernandes, Carlos Viana Poyares Jardim, Pedro Caruso
Summary: This study found that high-risk ESC/ERS risk assessment and SOFA score upon ICU admission are associated with in-hospital mortality in patients with PAH and CTEPH. A decision tree based on ESC/ERS risk assessment and SOFA score can identify four groups with in-hospital mortality ranging from 8.1% to 100%.
RESPIRATORY MEDICINE (2021)
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Editorial Material Rheumatology
Reply to: Mortality and prognostic factors in connective tissue disease-associated pulmonary arterial hypertension patients complicated with right heart failure
Marcos Vinicius Fernandes Garcia, Rogerio Souza, Pedro Caruso
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2023)
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Editorial Material Critical Care Medicine
Long-term survival after acute decompensated pulmonary hypertension: A propensity-score matched study
M. V. F. Garcia, R. Souza, P. Caruso
MEDICINA INTENSIVA (2023)
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Letter Respiratory System
Predictors of invasive mechanical ventilation use in patients with acute decompensated pulmonary hypertension admitted to the intensive care unit
Marcos V. F. Garcia, Rogerio Souza, Pedro Caruso
ERJ OPEN RESEARCH (2023)
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Article Cardiac & Cardiovascular Systems
Lung ultrasonography derived B-line scores as predictors of left ventricular end-diastolic pressure and pulmonary artery wedge pressure
Marcos V. F. Garcia, Jonathan Wiesen, Siddharth Dugar, Jacob R. Adams, Corinne Bott-Silverman, Ajit Moghekar, Adriano R. Tonelli
Summary: This study investigated the use of lung ultrasonography (LUS) for predicting left ventricular end-diastolic pressure (LVEDP) and pulmonary artery wedge pressure (PAWP). The results showed that LUS-derived B-line scores were moderately correlated with LVEDP and PAWP. A B-line index >= 28 can be used to predict elevated LVEDP and PAWP with high specificity.
RESPIRATORY MEDICINE (2023)
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Article Critical Care Medicine
Simulation-based Assessment to Measure Proficiency in Mechanical Ventilation among Residents
Fatima K. Hayashi, Mayson L. A. Sousa, Marcos V. F. Garcia, Bruno R. Macedo, Juliana C. Ferreira
Summary: This study developed and validated a simulation-based assessment on mechanical ventilation using a pulmonary simulator and a mechanical ventilator. It found that residents performed lower in practical skills of MV compared to theoretical knowledge exams, emphasizing the need for greater emphasis on practical skills during residency.
ATS SCHOLAR (2022)
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Article Respiratory System
Rapidly fatal disseminated histoplasmosis presenting as acute respiratory distress syndrome in a patient with HIV
Marcos Garcia
Summary: Patients with AIDS are susceptible to opportunistic infections like disseminated histoplasmosis. This case highlights the importance of accurate diagnosis in critically-ill patients and emphasizes the significance of autopsy findings in increasing our understanding of this rare and severe disease.
MINERVA RESPIRATORY MEDICINE (2022)
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Letter Respiratory System
External validation of the OPALS prediction model for in-hospital mortality in patients with acute decompensated pulmonary hypertension
Marcos V. F. Garcia, Rogerio Souza, Pedro Caruso
ERJ OPEN RESEARCH (2022)
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Meeting Abstract Critical Care Medicine
Prognostic Factors and Hospital Mortality in Patients with Acute Decompensated Pulmonary Arterial Hypertension Admitted to ICU
M. Garcia, B. R. Macedo, R. Souza, P. Caruso
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)
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Meeting Abstract Critical Care Medicine
Don't Stop Anticoagulation - Recurrent Pulmonary Embolism in a Patient with Granulomatosis with Polyangiitis
M. Garcia, J. G. Costa, T. V. Pereira, C. G. Rodrigues, C. S. V. Barbas
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)
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Meeting Abstract Respiratory System
Cases series on nontuberculous mycobacterial (NTM) lung disease and silicosis in Brazil
Diana Arrais de Souza Rangel, Marcos Vinicius Fernandes Garcia, Rafael Futoshi Mizutani, Roberta Karla Barbosa Sales, Ubiratan de Paula Santos, Mario Terra-Filho
EUROPEAN RESPIRATORY JOURNAL (2017)
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Meeting Abstract Respiratory System
Silicosis with acute renal injury and glomerulonephritis: a case report
Fernanda Coccolin, Fernando Soares, Rafael Mizutani, Cristiane Dias, Marcos Garcia, Mario Terra-Filho, Ubiratan Santos, Rafaela Pinheiro
EUROPEAN RESPIRATORY JOURNAL (2017)
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Article Respiratory System
Implementation of Tele-ICU during the COVID-19 pandemic
Bruno Rocha de Macedo, Marcos Vinicius Fernandes Garcia, Michelle Louvaes Garcia, Marcia Volpe, Mayson Laercio de Araujo Sousa, Talita Freitas Amaral, Marco Antonio Gutierrez, Antonio Pires Barbosa, Paula Gobi Scudeller, Pedro Caruso, Carlos Roberto Ribeiro Carvalho
Summary: This study describes the implementation of a Tele-ICU program during the COVID-19 pandemic and analyzes the results from the first four months of operation. The program, which aimed to standardize care for COVID-19 patients, was successfully implemented with evidence-based design and remote training for participants. Over 100,000 views on online platforms were recorded, and 326 COVID-19 patients were evaluated, with an ICU mortality rate of 65%. The Tele-ICU program provided multidisciplinary training and clinical follow-up for critically ill patients, demonstrating feasibility and encouraging the development of similar evidence-based projects.
JORNAL BRASILEIRO DE PNEUMOLOGIA (2021)
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Article Cardiac & Cardiovascular Systems
Evidence-informed development of women-focused cardiac rehabilitation education
Gabriela Lima de Melo Ghisi, Andree-Anne Hebert, Paul Oh, Tracey Colella, Crystal Aultman, Carolina Carvalho, Rajni Nijhawan, Marie-Kristelle Ross, Sherry L. Grace
Summary: This study aimed to co-design women-focused cardiac rehabilitation (CR) education to meet their specific needs. Through literature review, needs assessment, and content development, the research team created open-access educational resources including videos and slide decks. These resources will be used to support women in reducing their risk of cardiovascular sequelae.
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
High level of psychosocial adjustment in patients on ongoing ventricular assist device support in the years one to three after VAD implantation-A national multi-center Study
Hannah Spielmann, Wolfgang Albert, Sandra Semmig-Koenze, Volker Lauenroth, Christine Spitz-Koeberich, Paulina Staus, Katharina Tigges-Limmer, Christiane Kugler, S. E. L. M. A. Study SELMA Study Grp
Summary: This study investigated the construct of psychosocial adjustment and the role of social support in patients with durable VAD support. The results showed that the majority of the participants reported high levels of perceived social support and good psychosocial adjustment. Higher levels of perceived social support were associated with lower levels of anxiety and depression, and higher levels of quality of life.
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
Urban Zen integrative therapy: Understanding intervention delivery adherence
Tania T. Von Visger, Ji Won Shin, Mary Beth Happ
Summary: This study explores the perspectives of Urban Zen Integrative Therapy interventionists on the delivery of the therapy, aiming to gain a deeper understanding of subjective variables that may influence intervention fidelity. The results reveal several key themes related to adherence to the intervention delivery, such as balancing between tailoring and standardization, challenges faced during delivery, the need for teamwork, and clients' application of the therapy.
HEART & LUNG (2024)
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Review Cardiac & Cardiovascular Systems
Effects of ventilatory bundles on patient outcomes among ICU patients: A systematic review and meta-analysis
Dejina Thapa, Sek Ying Chair, Mei Sin Chong, Rishi Ram Poudel, Tenaw Gualau Melesse, Kai Chow Choi, Hon Lon Tam
Summary: The ventilator bundle has been found to effectively reduce the incidence of ventilator-associated pneumonia and improve related outcomes. However, caution should be exercised in interpreting these findings due to the low-to-moderate certainty of evidence and high heterogeneity.
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
Causal relationship between asthma and inflammatory bowel disease : A two-sample bidirectional mendelian randomization analysis
Jianxiong Lai, Bin Fang, Lirong Luo, Wenjie Xie, Yuanhui Xu, Jian Li
Summary: This study used two-sample bidirectional mendelian randomization to explore the causal link between asthma and inflammatory bowel disease. The researchers found a negative correlation between asthma and Crohn's disease. However, further research is needed to confirm this finding.
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
Which Components of The International Classification of Functioning, Disability and Health (ICF) are Covered by Cardiac Rehabilitation Assessment Tools among Individuals with Heart Failure?
Eriadina Alves Lima, Gezabell Rodrigues, Beatriz Carneiro Mota, Shamyr Sulyvan Castro, Rafael Barreto Mesquita, Camila Ferreira Leite
Summary: This study investigated the components of the International Classification of Functioning, Disability and Health (ICF) reflected in the assessment instruments used in cardiac rehabilitation for individuals with heart failure (HF). The results showed that body function was the most frequently detected component, but none of the instruments covered all aspects of the ICF. The Minnesota Living with Heart Failure Questionnaire (MLHFQ) demonstrated the most comprehensive coverage of ICF components.
HEART & LUNG (2024)
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Review Cardiac & Cardiovascular Systems
Sedation and analgesia strategies for non-invasive mechanical ventilation: A systematic review and meta-analysis
Baolu Yang, Leyi Gao, Zhaohui Tong
Summary: The use of sedative and analgesic medications during non-invasive ventilation can reduce the risk of tracheal intubation and delirium in patients with acute respiratory failure. Among the different medications, dexmedetomidine showed better clinical outcomes, especially when closely monitoring the patients' vital signs.
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
The psychometric properties of the Chinese version of the Interoceptive Awareness Questionnaire (IAQ) among cardiovascular disease
Liu Huang, Mengtao Song, Ling Wang, Qiran Zhang, Xiao Liu, Chunfeng Cai
Summary: This study examines the reliability and validity of the Chinese Interoceptive Awareness Questionnaire (C-IAQ) for Chinese cardiovascular disease (CVD) patients. The results indicate that the C-IAQ has favorable psychometric features and can be used to measure the interoceptive awareness of CVD patients.
HEART & LUNG (2024)
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Review Cardiac & Cardiovascular Systems
Effects of rapid response team on patient outcomes: A systematic review
Qiuxia Zhang, Khuan Lee, Zawiah Mansor, Iskasymar Ismail, Yi Guo, Qiao Xiao, Poh Ying Lim
Summary: This study conducted a systematic review to understand the effect of rapid response teams (RRT) on patient outcomes. The results showed that, despite variation in context and intervention type, most studies demonstrated that RRT positively impacts patient outcomes.
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
Serum proteomic analysis in esophagectomy patients with postoperative delirium: A case-control study
Sikandar H. Khan, Anthony J. Perkins, Samreen Jawaid, Sophia Wang, Heidi Lindroth, Rebecca E. Schmitt, Jason Doles, Jason D. True, Sujuan Gao, Gideon A. Caplan, Homer L. Twigg III, Kenneth Kesler, Babar A. Khan
Summary: This study aimed to identify protein pathways associated with delirium post-esophagectomy. The findings revealed that coagulation factor IX and mannosyl-oligosaccharide 1,2-alpha-mannosidase were associated with delirium, while complement C2 and mannosyl-oligosaccharide 1,2-alpha-mannosidase were associated with delirium severity.
HEART & LUNG (2024)
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Review Cardiac & Cardiovascular Systems
Efficacy and safety of fluticasone propionate/salmeterol and fluticasone propionate monotherapy in step-up treatment of childhood asthma: A systematic review and meta-analysis
Hua Li, Tao Dong, Jinling Luan
Summary: Fluticasone propionate and salmeterol (FSC) are viable options for step-up treatment in asthmatic children, as they can reduce the incidence of asthma exacerbations and improve lung function. FSC treatment for more than 12 weeks shows a greater likelihood of reducing asthma exacerbations and decreasing the use of albuterol. There were no significant differences in drug-related adverse events between FSC and fluticasone propionate (FP) alone.
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
Cardiac rehabilitation phase II outcomes prior and during COVID
Harrison Krebs, Kimberly Crutcher, Yan Su, Marilyn A. Prasun
Summary: During the COVID pandemic, patients experienced increased depression and poorer quality of life. However, significant improvements were observed in all outcomes following completion of Cardiac Rehabilitation (CR).
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
Lung ultrasound score for monitoring the withdrawal of extracorporeal membrane oxygenation on neonatal acute respiratory distress syndrome
Hong-Lin Wu, Si-Jia Zhou, Xiu-Hua Chen, Hua Cao, Yi-Rong Zheng, Qiang Chen
Summary: This study aimed to evaluate the value of LUS score at VA-ECMO withdrawal in neonatal ARDS patients. The results showed that LUS score significantly improved during VA-ECMO treatment and could be used to evaluate various lung diagnostic signs. Additionally, LUS score was positively correlated with ECMO blood flow and could predict ECMO weaning success.
HEART & LUNG (2024)
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Article Cardiac & Cardiovascular Systems
A family intervention to prevent postoperative delirium in patients undergoing cardiac valve surgery: A randomized controlled study
Lingyu Lin, Yanchun Peng, Xizhen Huang, Sailan Li, Liangwan Chen, Yanjuan Lin
Summary: This study aimed to investigate the effects of family intervention on the incidence of postoperative delirium (POD) and ICU prognoses of patients undergoing cardiac valve surgery. The results showed that family intervention could reduce the incidence of POD, shorten ICU stays, reduce the incidence of anxiety and depression in family caregivers, and improve their satisfaction. Therefore, family intervention is of significant importance for patients undergoing cardiac valve surgery.
HEART & LUNG (2024)
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